Contractors began to tear down the old Kaier's Brewery in Mahanoy City located on North Main Street around 12:15pm Tuesday, when the listed building began to crumble on it's own.
The possible collapse had officials close off a 6 block radius around the structure and to evacuate homes nearby.
A child development center nearby was also evacuated.
In all, 21 people are displaced, 17 are staying at a hotel with help from the American Red Cross, 4 others have places to stay.
Park Place Road, Route 339 North and South and North Main Street are closed until further notice.
As of 9:00pm Tuesday, chunks of the building could still be seen falling off the building.
The building was set to be tore down to create a park in the area. The money behind the project was secured through a grant.
Kaier's Brewery closed in the 1960's and has been abandoned since.