Around midnight, Monday, fire crews were called to 64 Malones Road, near Ashland for a working structure fire. When they arrived they found the home fully engulfed in flames.
A woman and her 4 children lived in the home.
The woman was taken via helicopter to an area hospital with burns.
Fire crews from Schuylkill, Columbia, and Northumberland came to aid in fighting the fire.
Crews remained on scene for over 2 hours until clearing after 2:00AM.
A State Police Fire Marshal is scheduled to be on scene Monday to determine the cause of the blaze.