The crash occurred just before 8:00am in the area of the southbound off ramp at Exit 100/Pine Grove and involving a van that crashed into the back of tractor trailer.
According to radio traffic, fire personnel arrived to find one person in the van heavily entrapped and unresponsive. A short time late, a county coroner was called to the scene.
Interstate 81 southbound is being closed at Exit 100.
UPDATE: As of 1:30pm, The interstate has reopened.
More information as it becomes available.